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Macos Sequoia 15.0 and office 365 - not responding

Since installing macOS Sequoia (15.0), I've had a problem when I open a Microsoft Word, Excel and PowerPoint file with Office 365 (latest version 16.89). The application doesn't respond. I have to force it to quit and open again: MS Word opened the file correctly. I've reinstalled Office several times, but the problem persists. In general, I can open one file, then application not responding.

Mac Studio, macOS 14.7

Posted on Sep 25, 2024 7:49 AM

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Question marked as Top-ranking reply

Posted on Oct 2, 2024 6:43 PM

This worked for me: Open the Terminal and run the following commands:

/System/Library/Frameworks/CoreServices.framework/Versions/A/Frameworks/LaunchServices.framework/Versions/A/Support/lsregister -kill -r -domain local -domain system -domain user 


sudo /System/Library/Frameworks/CoreServices.framework/Frameworks/LaunchServices.framework/Support/lsregister -kill -seed -lint -r -f -v -dump -domain local -domain system -domain user -domain network


killall Dock


56 replies

Nov 8, 2024 6:56 AM in response to BahadirT

Thank you for this. I tried to do "open with" and did indeed see that "recommended apps" was the option. I changed that to "all apps" and opened the app. I was hopeful that this would magically address my problem too which is not actually opening files but saving a copy (and saving new files as well), but, alas, it did not.

Please keep the suggestions coming folks. This is a horrible experience for everyone - and I just got my first Mac in decades right before the update, not a good way to start a renewed relationship. ugh

Oct 2, 2024 6:12 AM in response to PhMil

I used to Use Office 2016 permanent license products and use perfectly, unit with Sequoia 15.0,

After that .docx and .xlsx files became idle.

When I try to ask, "please choose app" notification pop-up.

I felt like 2016 in not compatible with Sequoia 15.0.

I bought Office 2021 permanent license

Deleted 2016 and installed 2021.

Still same, nothing changed.

I still can't open .docx and .xlsx intention files.

.ppt is working interestingly.

I send complaint to Office support desk.

No reply.


Oct 5, 2024 11:22 PM in response to Anakrasni

Search Terminal in Mac and

This worked for me: Open the Terminal and run the following commands:

enter below 2 lines and click enter

/System/Library/Frameworks/CoreServices.framework/Versions/A/Frameworks/LaunchServices.framework/Versions/A/Support/lsregister -kill -r -domain local -domain system -domain user 


Now enter below 2 lines and click enter, Let it run 2 mins and quit terminal it will fix issue

sudo /System/Library/Frameworks/CoreServices.framework/Frameworks/LaunchServices.framework/Support/lsregister -kill -seed -lint -r -f -v -dump -domain local -domain system -domain user -domain network

Oct 20, 2024 7:21 AM in response to PhMil

How I Fixed It


Since upgrading to macOS Sequoia (15.0.1), I’ve been facing issues with Microsoft Office 365 (version 16.89). Every time I tried opening a Word, Excel, the application wouldn’t respond, forcing me to quit and restart it. After reinstalling Office multiple times without any luck, I finally found a solution: resetting macOS to factory settings.


To fix the issue, I went to Settings > General > Transfer or Reset, and did a full reset. After that, Office 365 began working as expected, allowing me to open and work on files without freezing.


This process solved the problem for me, so if anyone else is facing similar issues, it might be worth a try!

Nov 8, 2024 6:59 AM in response to JoBremen

I am able to use the online version as well. Otherwise I would also have to use a Windows machine.

This is still incredibly inconvenient since the apps are not the same and it seems like the online apps don't have all of the features the desktop ones do (or at least I don't have time to figure out where they are hiding). At least I can go to the online app to create and save a file and then use the desktop to continue. No save as and I can't export a file to another format (like PowerPoint to mp4 or Word to pdf or Excel to csv).

Macos Sequoia 15.0 and office 365 - not responding

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