Microsoft Office 2021

Yes.

Also see the following from the "Office 2021 suites" section of https://www.microsoft.com/en-us/microsoft-365/microsoft-365-and-office-resources?ms.url=m365cominformation&rtc=1#coreui-heading-1hdaxqh

macOS: Office for Mac is supported on the three most recent versions of macOS. As new major versions of macOS are made generally available, Microsoft will drop support for the oldest version and support the newest and previous two versions of macOS. Product functionality and feature availability may vary on older systems. For the best experience, use the latest version of any operating system specified above.